Prof. Dr. med. Pierre-Alain Clavien

Auszeichnungen und Sonderpreise (insgesamt >25)

• Otto Naegeli Prize, 2008 (CHF 250’000) 
• Gimbernat Prize, 2011, given by the Societat Catalana de Cirurgia 
• UEGF Research Prize ($150’000), given by the European federation of Gastroenterology
• Innovation prize in transplantation, 2012, given by the Transplantation Society TTS 
• Annual Award of the Swiss Surgical Society, 1989 ($10’000) 

Wyss translational center projects (5 relevant papers)

• Clavien P-A, Dutkowski P, Tibbitt MW et al. Transplantation of a human liver following 3 days of ex situ normothermic preservation. Nature Biotechnol. 2022; 40: 1610–1616.  
• Eshmuminov D, Clavien P-A et al. An integrated perfusion machine preserves injured human livers for 1 week. Nat Biotechnol. 2020; 38: 189-198.
• Eshmuminov D, Clavien P-A. Long-term dynamic ex vivo organ preservation. Nat Rev Gastroenterol Hepatol. 2022; doi: 10.1038/s41575-022-00727-2.
• Mueller M, Clavien P-A et al. Long-term Normothermic Machine Preservation of Partial Livers: First Experience With 21 Human Hemi-livers. Ann Surg. 2021; 274: 836-842.
• Sousa Da Silva RX, Clavien P-A et al. Defatting of Human Livers during Long-Term ex situ Normothermic Perfusion. Novel Strategy to Rescue Discarded Organs for Transplantation. Ann Surg. 2023; Accepted for publication.

Basic research (7 relevant papers)

• Schneider MA, Heeb L, Gupta A and Clavien P-A et al. Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models. Science Translational Medicine 2021; 13 (611): eabc8188.
• Linecker M, Clavien P-A. Exercise improves outcomes of surgery on fatty liver in mice – a novel effect mediated by the AMPK pathway. Annals of Surgery. 2020; 271: 347-55.
• Langiewicz M, Humar B, Clavien P-A. JNK1 induces hedgehog signaling from stellate cells to accelerate liver regeneration in mice. J Hepatol. 2018; 69: 666-675.
• Kachaylo E, Clavien P-A, Humar B. PTEN down-regulation promotes β-oxidation to fuel hypertrophic liver growth after hepatectomy in mice. Hepatology. 2017; 66: 908-921.
• Langiewicz M, Humar B, Clavien P-A. Hedgehog pathway mediates early acceleration of liver regeneration induced by a novel two-staged hepatectomy in mice. J Hepatol. 2017; 66: 560-570.
• Dutkowski P, Schlegel A, de Oliveira M, Müllhaupt B, Neff F, P-A Clavien. HOPE for human liver grafts obtained from donors after cardiac death. J Hepatol. 2014; 60, 765-772.
• Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, Gachet C, Clavien P-A et al. Platelet-derived serotonin mediates liver regeneration. Science. 2006; 312 (5770): 104-107. 

Outcome research (7 relevant papers)

• Domenghino A, Walbert C, Birrer D, Puhan MA, Clavien P-A. Consensus recommendations on how to assess the quality of surgical interventions. Nature Medicine. 2023; 29: 811-822.
• Staiger RD, Schwandt H, Puhan MA, Clavien P-A. Improving surgical outcomes through benchmarking. Br J Surg. 2019; 106: 59-64. 
• Raptis DA, Clavien P-A et al. Defining Benchmark Outcomes for ALPPS. Ann Surg. 2019; 270: 835-841.
• Muller X, Clavien P-A et al. Defining Benchmarks in Liver Transplantation: A Multicenter Outcome Analysis Determining Best Achievable Results. Ann Surg. 2018; 267: 419-425.
• Rössler F, Clavien P-A et al. Defining Benchmarks for Major Liver Surgery: A multicenter Analysis of 5202 Living Liver Donors. Ann Surg. 2016; 264: 492-500. 
• Slankamenac K, Graf R, Barkun J, Puhan MA, Clavien P-A. The comprehensive complication index: a novel continuous scale to measure surgical morbidity. Ann Surg. 2013; 258: 1-7.
• Dindo D, Demartines N, Clavien P-A. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004; 240: 205-213.

Others (5 relevant papers)

• Clavien P‐A, J. Deiss. Consensus on how to select a chair for medicine. Ten tips for choosing an academic chair. Nature. 2015; 519(7543): 286‐287.
• Vetter D, Clavien P-A et al. Effects of Art on Surgical Patients: A Systematic Review and Meta-analysis. Ann Surg. 2015; 262: 704-13.
• Von Websky MW, Clavien P-A et al. Trainee satisfaction in surgery residency programs: Modern management tools ensure trainee motivation and success. Surgery. 2012; 152: 794-801.
• Raptis DA, Clavien P-A et al. Job satisfaction among young board-certified surgeons at academic centers in Europe and North America. Ann Surg. 2012; 256: 796-805.
• Tschuor C, Clavien P-A et al. Job satisfaction among chairs of surgery from Europe and North America. Surgery. 2014; 156: 1069-1077

500 gehaltene Vorträge weltweit

• State of the Art Lecture: «Staging of cholangiocarcinoma by PET-scan FDG. » Consensus Conference of the European Hepato Pancreato Biliary Association (EHPBA), Brussels, Belgium, 01.12.2007. 
• Tom E Starzl State of the Art lecture: «What is critical for liver surgery and partial liver transplantation – size or quality?» 60th Annual Meeting of American Association for the Study of the Liver (AASLD), Boston, USA, 30.10.-03.11.2009. 
• Opening Lecutre: «State of the art: breakthrough innovations», Opening of the Erasmus MC Transplant Institute, Rotterdam, Netherlands, 28.10.2021. 
• Keynote Lecture: «Classification of Complications and Benchmarking, Transplantation after "failed" ALPPS». AHPBA 2018 Annual Meeting, Miami, USA, 07.-11.03.2018. 
• Henrik Kehlet Keynote Lecture: «New concept of benchmarking in surgery». 6th ERAS World Congress, Stockholm, Sweden, 23.-25.03.2018. 
• Keynote Lecture: «Limits of pancreatic surgery» and Lecture: «How to assess outcome in surgery – Who is good, who is bad?», Pharmaceutical, Medical, Dental Congress & Exhibition Middle East, Erbil, Iraq, 02.-05.05.2019. 
• Keynote Lecture: «What are the Essential Requirements for an HPB Service to Deliver Quality Outcomes» and «MEET THE PROFESSOR: Three types of hepatectomy to solve most indications, but which one to choose! », IHPBA 2020, Melbourne, Australia, Online, 27.-29.11.2020.  
• Keynote Lecture: «Surgical indications and management of solid benign liver tumours – Benign lesions of liver and pancreas». Royal Belgian Society of Surgery Hepato-Biliary and Pancreatic Section (BSHBPS), Brussels, Belgium, 27.11.2009. 
• Keynote Lecture: Pump Symposium for chemotherapy: «HAIP chemotherapy, Benchmarking pancreas surgery», Congress of the E-AHPBA, Amsterdam, Netherlands, 02.-05.06.2019. 
• Keynote robotic liver surgery: «Limits and perspectives: When is MIS Liver Surgery Better?», CRSA Webinar 2020, Online, 30.09.2020. 

• Betreuung von mehr als 45 Doktoranden (10 an der Duke University, 35 an der Universität Zürich) 
• Ausbildung von 30 klinischen Fellows, die heute weltweit führende Positionen innehaben 
• Lehre und Ausbildung in komplexer Leber- und Pankreaschirurgie 

Sowie mehrere Bücher und Atlanten, darunter der Atlas des oberen Gastrointestinaltrakt und Hepatobiliäre Chirurgie. 3. Auflage mit neuem Kapitel zur Robotertechnik in Vorbereitung. 

Alle Publikationen (>750) von Prof. Dr. med. Pierre-Alain Clavien finden Sie hier. 

Klinisch (14 relevante Papers) 

• Clavien P-A, et al. Strategies for safer liver surgery and partial liver transplantation. N Engl J Med. 2007; 356: 1545-59. 
• Petrowsky H, Clavien P‐A et al. Modern therapeutic approaches for the treatment of malignant liver tumours. Nat Rev Gastroenterol Hepatol. 2020; 17: 755-772.
• Clavien P-A, et al. State of the art Starzl lecture: What is critical for liver surgery and partial liver transplantation: Size or quality? Hepatology. 2010; 52: 715-29. 
• Eshmuminov D, Raptis DA, Linecker M, Wirsching A, Lesurtel M, Clavien P-A. Meta-analysis of associating liver partition with portal vein ligation and portal vein occlusion for two-stage hepatectomy. Br J Surg. 2016; 103(13): 1768-1782. 
• Ignatavicius P, Clavien P-A et al. Choices of Therapeutic Strategies for Colorectal Liver Metastases among Expert Liver Surgeons: A Throw of the Dice? Ann Surg. 2020; 272: 715-722. 
• Petrowsky H. First Long-term Oncologic Results of the ALPPS Procedure in a Large Cohort of Patients with Colorectal Liver Metastases. Ann Surg. 2020; 272: 793-800. 
• Raptis DA, Clavien P-A et al. Defining Benchmark Outcomes for Pancreatoduodenectomy with Portomesenteric Venous Resection. Ann Surg. 2020; 272: 731-737. 
• Linecker M, Clavien P-A et al. Perioperative omega-3 fatty acids fail to confer protection in liver surgery: Results of a multicentric, double-blind, randomized controlled trial. J Hepatol. 2020; 72: 498-505. 
• Sánchez-Velázquez P, Clavien P-A et al. Benchmarks in Pancreatic Surgery: A Novel Tool for Unbiased Outcome Comparisons. Ann Surg. 2019; 270: 211-218.
• Dindo D, Müller MK, Weber M, Clavien P-A. Obesity in general elective surgery: Lancet. 2003, 361:2032-35. 
• Heinrich S, Clavien P-A et al. Prospective phase II trial neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head. J Clin Oncology. 2008, 26, 760-69. 
• DeOliveira ML, Schulick RD, Nimura Y, Rosen C, Gores G, Neuhaus P and Clavien P-A. New staging system and a registry for perihilar cholangiocarcinoma. Hepatology. 2011; 53: 1363-71. 
• Kron P, Clavien P-A et al. PA. Ablation or Resection for Colorectal Liver Metastases? A Systematic Review of the Literature. Front Oncol. 2019; 9: 1052. 
• Clavien P-A, Selzner M. End-to-end pancreatico-duodenostomy: an alternative reconstruction for partial resection of the head of the pancreas. Journal of the American College of Surgeons. 1998; 187: 330-332. 

• «Unser Ziel ist, das europaweit beste Fachwissen anzubieten», Schweizerische Ärztezeitung, 2023 
• Liverreport, Issue 4, 2022 
• «Der Patient spielt keine Rolle mehr», NZZ, 2020 
• «Le bien-être des patients ne cesse de s’améliorer», L’illustré, 2018 
• «Pierre Clavien: first a surgeon, and first a scientist», Lancet