Prof. Dr. med. Pierre-Alain Clavien

Awards and special prizes (total >25)

• Otto Naegeli Prize, 2008 (CHF 250’000) 
• Gimbernat Prize, 2011, given by the Societat Catalana de Cirurgia 
• UEGF Research Prize ($150’000), given by the European federation of Gastroenterology
• Innovation prize in transplantation, 2012, given by the Transplantation Society TTS 
• Annual Award of the Swiss Surgical Society, 1989 ($10’000) 

Wyss translational center projects (5 relevant papers)

• Clavien P-A, Dutkowski P, Tibbitt MW et al. Transplantation of a human liver following 3 days of ex situ normothermic preservation. Nature Biotechnol. 2022; 40: 1610–1616.  
• Eshmuminov D, Clavien P-A et al. An integrated perfusion machine preserves injured human livers for 1 week. Nat Biotechnol. 2020; 38: 189-198.
• Eshmuminov D, Clavien P-A. Long-term dynamic ex vivo organ preservation. Nat Rev Gastroenterol Hepatol. 2022; doi: 10.1038/s41575-022-00727-2.
• Mueller M, Clavien P-A et al. Long-term Normothermic Machine Preservation of Partial Livers: First Experience With 21 Human Hemi-livers. Ann Surg. 2021; 274: 836-842.
• Sousa Da Silva RX, Clavien P-A et al. Defatting of Human Livers during Long-Term ex situ Normothermic Perfusion. Novel Strategy to Rescue Discarded Organs for Transplantation. Ann Surg. 2023; Accepted for publication.

Basic research (7 relevant papers)

• Schneider MA, Heeb L, Gupta A and Clavien P-A et al. Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models. Science Translational Medicine 2021; 13 (611): eabc8188.
• Linecker M, Clavien P-A. Exercise improves outcomes of surgery on fatty liver in mice – a novel effect mediated by the AMPK pathway. Annals of Surgery. 2020; 271: 347-55.
• Langiewicz M, Humar B, Clavien P-A. JNK1 induces hedgehog signaling from stellate cells to accelerate liver regeneration in mice. J Hepatol. 2018; 69: 666-675.
• Kachaylo E, Clavien P-A, Humar B. PTEN down-regulation promotes β-oxidation to fuel hypertrophic liver growth after hepatectomy in mice. Hepatology. 2017; 66: 908-921.
• Langiewicz M, Humar B, Clavien P-A. Hedgehog pathway mediates early acceleration of liver regeneration induced by a novel two-staged hepatectomy in mice. J Hepatol. 2017; 66: 560-570.
• Dutkowski P, Schlegel A, de Oliveira M, Müllhaupt B, Neff F, P-A Clavien. HOPE for human liver grafts obtained from donors after cardiac death. J Hepatol. 2014; 60, 765-772.
• Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, Gachet C, Clavien P-A et al. Platelet-derived serotonin mediates liver regeneration. Science. 2006; 312 (5770): 104-107. 

Outcome research (7 relevant papers)

• Domenghino A, Walbert C, Birrer D, Puhan MA, Clavien P-A. Consensus recommendations on how to assess the quality of surgical interventions. Nature Medicine. 2023; 29: 811-822.
• Staiger RD, Schwandt H, Puhan MA, Clavien P-A. Improving surgical outcomes through benchmarking. Br J Surg. 2019; 106: 59-64. 
• Raptis DA, Clavien P-A et al. Defining Benchmark Outcomes for ALPPS. Ann Surg. 2019; 270: 835-841.
• Muller X, Clavien P-A et al. Defining Benchmarks in Liver Transplantation: A Multicenter Outcome Analysis Determining Best Achievable Results. Ann Surg. 2018; 267: 419-425.
• Rössler F, Clavien P-A et al. Defining Benchmarks for Major Liver Surgery: A multicenter Analysis of 5202 Living Liver Donors. Ann Surg. 2016; 264: 492-500. 
• Slankamenac K, Graf R, Barkun J, Puhan MA, Clavien P-A. The comprehensive complication index: a novel continuous scale to measure surgical morbidity. Ann Surg. 2013; 258: 1-7.
• Dindo D, Demartines N, Clavien P-A. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004; 240: 205-213.

Others (5 relevant papers)

• Clavien P‐A, J. Deiss. Consensus on how to select a chair for medicine. Ten tips for choosing an academic chair. Nature. 2015; 519(7543): 286‐287.
• Vetter D, Clavien P-A et al. Effects of Art on Surgical Patients: A Systematic Review and Meta-analysis. Ann Surg. 2015; 262: 704-13.
• Von Websky MW, Clavien P-A et al. Trainee satisfaction in surgery residency programs: Modern management tools ensure trainee motivation and success. Surgery. 2012; 152: 794-801.
• Raptis DA, Clavien P-A et al. Job satisfaction among young board-certified surgeons at academic centers in Europe and North America. Ann Surg. 2012; 256: 796-805.
• Tschuor C, Clavien P-A et al. Job satisfaction among chairs of surgery from Europe and North America. Surgery. 2014; 156: 1069-1077

500 lectures held worldwide

• State of the Art Lecture: «Staging of cholangiocarcinoma by PET-scan FDG. » Consensus Conference of the European Hepato Pancreato Biliary Association (EHPBA), Brussels, Belgium, 01.12.2007. 
• Tom E Starzl State of the Art lecture: «What is critical for liver surgery and partial liver transplantation – size or quality?» 60th Annual Meeting of American Association for the Study of the Liver (AASLD), Boston, USA, 30.10.-03.11.2009. 
• Opening Lecutre: «State of the art: breakthrough innovations», Opening of the Erasmus MC Transplant Institute, Rotterdam, Netherlands, 28.10.2021. 
• Keynote Lecture: «Classification of Complications and Benchmarking, Transplantation after "failed" ALPPS». AHPBA 2018 Annual Meeting, Miami, USA, 07.-11.03.2018. 
• Henrik Kehlet Keynote Lecture: «New concept of benchmarking in surgery». 6th ERAS World Congress, Stockholm, Sweden, 23.-25.03.2018. 
• Keynote Lecture: «Limits of pancreatic surgery» and Lecture: «How to assess outcome in surgery – Who is good, who is bad?», Pharmaceutical, Medical, Dental Congress & Exhibition Middle East, Erbil, Iraq, 02.-05.05.2019. 
• Keynote Lecture: «What are the Essential Requirements for an HPB Service to Deliver Quality Outcomes» and «MEET THE PROFESSOR: Three types of hepatectomy to solve most indications, but which one to choose! », IHPBA 2020, Melbourne, Australia, Online, 27.-29.11.2020.  
• Keynote Lecture: «Surgical indications and management of solid benign liver tumours – Benign lesions of liver and pancreas». Royal Belgian Society of Surgery Hepato-Biliary and Pancreatic Section (BSHBPS), Brussels, Belgium, 27.11.2009. 
• Keynote Lecture: Pump Symposium for chemotherapy: «HAIP chemotherapy, Benchmarking pancreas surgery», Congress of the E-AHPBA, Amsterdam, Netherlands, 02.-05.06.2019. 
• Keynote robotic liver surgery: «Limits and perspectives: When is MIS Liver Surgery Better?», CRSA Webinar 2020, Online, 30.09.2020. 

• Supervision of more than 45 PhD students (10 at Duke University, 35 at the University of Zurich)
• Training of 30 clinical fellows who are today in leading positions worldwide 
• Teaching and training in complex liver and pancreatic surgery 

As well as several books and atlases, including Atlas of the Upper Gastrointestinal Tract and Hepatobiliary Surgery. 3rd edition with new chapter on robotics in preparation.

All publications (> 750) by Prof. Pierre-Alain Clavien can be found here.

Clinical (14 relevant papers)

• Clavien P-A, et al. Strategies for safer liver surgery and partial liver transplantation. N Engl J Med. 2007; 356: 1545-59. 
• Petrowsky H, Clavien P‐A et al. Modern therapeutic approaches for the treatment of malignant liver tumours. Nat Rev Gastroenterol Hepatol. 2020; 17: 755-772.
• Clavien P-A, et al. State of the art Starzl lecture: What is critical for liver surgery and partial liver transplantation: Size or quality? Hepatology. 2010; 52: 715-29. 
• Eshmuminov D, Raptis DA, Linecker M, Wirsching A, Lesurtel M, Clavien P-A. Meta-analysis of associating liver partition with portal vein ligation and portal vein occlusion for two-stage hepatectomy. Br J Surg. 2016; 103(13): 1768-1782. 
• Ignatavicius P, Clavien P-A et al. Choices of Therapeutic Strategies for Colorectal Liver Metastases among Expert Liver Surgeons: A Throw of the Dice? Ann Surg. 2020; 272: 715-722. 
• Petrowsky H. First Long-term Oncologic Results of the ALPPS Procedure in a Large Cohort of Patients with Colorectal Liver Metastases. Ann Surg. 2020; 272: 793-800. 
• Raptis DA, Clavien P-A et al. Defining Benchmark Outcomes for Pancreatoduodenectomy with Portomesenteric Venous Resection. Ann Surg. 2020; 272: 731-737. 
• Linecker M, Clavien P-A et al. Perioperative omega-3 fatty acids fail to confer protection in liver surgery: Results of a multicentric, double-blind, randomized controlled trial. J Hepatol. 2020; 72: 498-505. 
• Sánchez-Velázquez P, Clavien P-A et al. Benchmarks in Pancreatic Surgery: A Novel Tool for Unbiased Outcome Comparisons. Ann Surg. 2019; 270: 211-218.
• Dindo D, Müller MK, Weber M, Clavien P-A. Obesity in general elective surgery: Lancet. 2003, 361:2032-35. 
• Heinrich S, Clavien P-A et al. Prospective phase II trial neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head. J Clin Oncology. 2008, 26, 760-69. 
• DeOliveira ML, Schulick RD, Nimura Y, Rosen C, Gores G, Neuhaus P and Clavien P-A. New staging system and a registry for perihilar cholangiocarcinoma. Hepatology. 2011; 53: 1363-71. 
• Kron P, Clavien P-A et al. PA. Ablation or Resection for Colorectal Liver Metastases? A Systematic Review of the Literature. Front Oncol. 2019; 9: 1052. 
• Clavien P-A, Selzner M. End-to-end pancreatico-duodenostomy: an alternative reconstruction for partial resection of the head of the pancreas. Journal of the American College of Surgeons. 1998; 187: 330-332. 

• «Unser Ziel ist, das europaweit beste Fachwissen anzubieten», Schweizerische Ärztezeitung, 2023 
• Liverreport, Issue 4, 2022 
• «Der Patient spielt keine Rolle mehr», NZZ, 2020 
• «Le bien-être des patients ne cesse de s’améliorer», L’illustré, 2018 
• «Pierre Clavien: first a surgeon, and first a scientist», Lancet