Dr. med. Antoine Leimgruber

Directeur du développement de la Médecine Nucléaire, Swiss Medical Network

Directeur Médical de Swiss Theranostics

Co-fondateur, Biopsomic SA

Chef de l'unité de Médecine Nucléaire et responsable de l'imagerie oncologique (Hopital Riviera-Chablais)

Médecin en formation et Fellow, Hôpital universitaire de Lausanne, Peter MacCallum Cancer Center, Austin Health, Center for Molecular Imaging Research & Center for Systems Biology, Harvard Medical School

Associé de recherche, Groupe de modélisation moléculaire, Institut suisse de bioinformatique et Ludwig Institute Lausanne

Ingénieur de projet, Système d'archivage et de communication d'images, Service de Radiologie, CHU de Lausanne

Consultant en mathématiques financières, Time-Steps SA, Zurich

Formation spécialisée :

• Fellow en imagerie hybride, Département d'imagerie du cancer, Peter MacCallum Cancer Center (Prof Hicks, Melbourne)
• Chef de clinique, Service of Nuclear Medicine & Ludwig Institute (Prof Rowe et Scott, Melbourne, Australie)
• Chef de clinique adjoint, Service de médecine nucléaire, CHU de Lausanne (Prof Prior, Suisse)
• Médecin assistant, Service de radiologie, CHU de Lausanne (Prof Schnyder, Meuli, Suisse)
• Fellow, Center for Molecular Imaging Research & Center for Systems Biology (Prof Pittet & Weissleder, Harvard Medical School, États-Unis)

Formation non spécialisée :

• Hôpital universitaire de Lausanne
• Massachusetts General Hospital (Boston, États-Unis)
• Institut d'oncologie de la Bolivie orientale (Santa Cruz, Bolivie)
• Ambulatorio Dr David Espinoza Rojas (Nueva Esparta, Venezuela)

Richard J Lobb, Kekoolani S Visan, Li-Ying Wu, Emma L Norris, Marcus L Hastie, Sarah Everitt, Ian A Yang, Rayleen V Bowman, Shankar Siva, Jill E Larsen, Jeffrey J Gorman, Michael MacManus, Antoine Leimgruber, Kwun M Fong, Andreas Möller, An epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer, Communications Biology 6 (1), 68

Gatta R, Depeursinge A, Ratib O, Michielin O, Leimgruber A, Integrating radiomics into holomics for personalised oncology: from algorithms to bedside, European Radiology Exp, 2020 Feb 07,4(11) - ~30 citations

Leimgruber A, Hickson K, Lee ST, Gan HK, Cher LM, Sachinidis JLO, O’Keefe GJ, Scott AM, Spatial and quantitative mapping of glycolysis and hypoxia in glioblastoma as a predictor of radiotherapy response and sites of relapse, EJNMMI, 2020 Feb 5;47(1476-1485) - ~15 citations

Wen Wen S, Everitt SJ, Bedö J, Chabrot M, Ball DL, Solomon B, MacManus M, Hicks RJ, Möller A and Leimgruber A, Spleen volume variation in patients with locally advanced non-small cell lung cancer receiving platinum-based chemo-radiotherapy, PLoS One. 2015 Nov 24;10(11) - ~20 citations

Lobb RJ, Becker M, Wen Wen S, Wong CSF, Wiegmans AP, Leimgruber A, Möller A, Optimized Exosome Isolation Protocol for Cell Culture Supernatant and Human Plasma, J Extracell Vesicles. 2015 Jul 17;4 - ~1250 citations

Leimgruber A, Möller A, Everitt S, Chabrot M, Ball D, Solomon B, MacManus M and Hicks R, Effect of platinum-based chemoradiotherapy on cellular proliferation in bone marrow and spleen, estimated by FLT-PET/CT in patients with locally advanced non-small cell lung cancer, J Nucl Med. 2014 May 27;55(7) - ~30 citations & Alavi-Mandell award

Leimgruber A, Ferber M, Irving M, Hussain-Kahn H, Wieckowski S, Rufer N, Zoete V and Michielin O, TCRep 3D: an automated in silico approach to study the structural properties of TCR repertoires, PloS One. 2011;6(10) - ~20 citations

Gambarota G, Perazzolo C, Leimgruber A, Meuli R, Mangin P, Augsburger M and Grabherr S, Non-invasive detection of dissolved cocaine in wine bottles by magnetic resonance spectroscopy, Drug Test Anal. 2010 Sep 30.

Leimgruber A, Berger C, Cortez-Retamozo V, Etzrodt M, Newton A, Waterman P, Figueiredo J, Kohler R, Elpek N, Mempel T, Swirski F, Nahrendorf M, Weissleder R and Pittet M, Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle, Neoplasia. 2009 May; 11(5) - ~120 citations & journal cover

Derré L, Bruyninx M, Baumgaertner P, Ferber M, Schmid D, Leimgruber A, Zoete V, Romero P, Michielin O, Speiser D and Rufer N, Structurally distinct TCRs confer similar recognition of the tumor-specific epitope NY-ESO-1157-165 by interacting with its central Met/Trp residues, Proc Natl Acad Sci U S A. 2008 Sep 30;105(39) - ~45 citations

Derré L, Ferber M, Touvrey C, Devevre E, Zoete V, Leimgruber A, Romero P, Michielin O, Lévy F and Speiser D, A novel population of human melanoma-specific CD8 T cells recognizes Melan-AMART-1 immunodominant nonapeptide but not the corresponding decapeptide, J Immunol, 2007 Dec 1;179(11) - ~30 citations

Leimgruber A, Ostermann S, Yeon EJ, Buff E, Maeder P, Stupp R and Meuli R, Perfusion and diffusion MRI of glioblastoma progression in a four-year prospective temozolomide clinical trial, Int J Radiat Oncol Biol Phys, 2006 Mar 1;64(3) - ~40 citations